The chemical name is 7-chloro-1,3-dihydrohydroxymethylphenyl-2H-1,4-benzodiazepinone, and the structural formula is: Temazepam is a white, crystalline substance, very slightly soluble in water and sparingly soluble in alcohol, USP.
Consumer medicine information
Temazepam capsules, 15 mg, or 30 mg, are for oral administration. There were no active metabolites formed and the only ificant metabolite present in blood was the O-conjugate.
The blood level decline of the parent drug was biphasic with the short half-life ranging from 0. Metabolites were formed with a half-life of 10 hours and excreted with a half-life of approximately 2 hours. Thus, formation of the major metabolite is taoe rate limiting step in the biodisposition of temazepam.
There is no accumulation of metabolites. In a 7 day study, in which subjects were given a 30 mg temazepam capsule 1 hour before retiring, steady-state as measured by the attainment of maximal trough concentrations was achieved by the third dose. A slight trend toward declining hour plasma levels was seen after day 4 in the study, however, the 24 hour plasma levels were quite variable.
Temaezpam a dose of 30 mg once-a-day for 8 weeks, no evidence of enzyme induction was found in man. Elimination Rate of Benzodiazepine Hypnotics and Profile of Common Untoward Effects The type and duration of hypnotic effects and the profile of unwanted effects during administration of benzodiazepine hypnotics may be influenced by the biologic half-life of the administered drug and for some hypnotics, the half-life of any active metabolites formed.
In contrast, if half-lives are shorter, drug and, where appropriate, its active metabolites will be cleared before the next dose is ingested, and carry-over effects related to excessive sedation or CNS depression should be minimal or absent. However, during nightly use Ho an extended period, pharmacodynamic tolerance or adaptation to some effects of benzodiazepine hypnotics may develop.
If the drug has a short elimination half-life, it is possible that a relative deficiency of the drug, or, if appropriate, its active temzaepam i. This sequence of events may for 2 clinical findings reported to occur after several weeks of nightly use of rapidly eliminated benzodiazepine hypnotics, namely, increased wakefulness during the last third of the night, and too appearance of increased s of daytime anxiety.
Controlled Trials Supporting Efficacy: Temazepam improved sleep parameters in clinical studies.
Early morning awakening, a particular problem in the geriatric patient, was ificantly reduced. Common questions How does temazepam work? Temazepam belongs to a group of medicines called benzodiazepines.
It works by increasing the levels of a calming chemical in your brain called gamma amino butyric acid GABA. This can make you feel drowsy and sleepy. How long does it take to work?
Consumer medicine information
It normally takes around 30 minutes to work. How long will I take temazepam for?
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Temazepam is usually prescribed for a short period of time of up to 4 weeks. Is temazepam addictive? Temazepam is not likely to be addictive if you take it at a low dose for a short time 2 to 4 weeks. You're more likely to get addicted if you have or have had problems with alcohol or drugs.
Apo-temazepam - nps medicinewise
It's also more likely if rake take more than your prescribed dose or take it for longer than 4 weeks. Are there other medicines for sleeping problems? ❶There was no evidence of tolerance development in the sleep laboratory parameters when patients were given temazepam nightly for at least 2 weeks.
Temaezpam I take temazepam with me if I'm travelling abroad? Are there foods and drinks I should avoid? How long does it take to work? Temazepam should be administered with caution in severely depressed patients or those in whom there is any evidence of latent depression; it should be recognized that suicidal tendencies may be present and protective measures may be necessary.
Temazepam interaction with food, herbs and alcohol
Temazepam is contraindicated in women who are or may become pregnant. Temazepam does not affect how contraception works, including the combined pill and emergency contraception. Will it affect my contraception? Tfmazepam with sleep-driving, patients usually do not remember these events. The usual precautions should be observed in patients with impaired renal or hepatic function and in patients with chronic pulmonary insufficiency.
How long does restoril (temazepam) stay in your system?
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Take this medication by mouth with or without food as directed by your doctor, usually just before you get into bed. The dosage is based on your medical condition.
Temazepam (oral route) proper use - mayo clinic
Take temazepam just before going to bed, when you are ready to go to sleep. This medicine works very quickly to put you to sleep. Do not take. This drug should be taken immediately before bedtime.
If you take it too early, you may feel sleepy before your bedtime. If you.